Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
نویسندگان
چکیده
No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient.
منابع مشابه
Duplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia.
The t(8;21)(q22;q22) results in the formation of RUNX1/ RUNX1T1 (alias AML1/ETO) and RUNX1T1/RUNX1 fusion genes on der(8)t(8;21)(q22;q22) and der(21)t(8;21)(q22;q 22), respectively. An 18-year-old woman was diagnosed as having acute myeloid leukemia (AML) M2, as her bone marrow was infiltrated with 42.2% myeloblasts. Auer rods were found in myeloblasts and metamyelocytes (Picture A, B, arrows)....
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